Posted: May 22nd, 2023

A fusion is then formed when the two or more genes

The other way that fusion proteins can be formed is through chimeric mutation. The process in which this mutation occurs is known as chromosome translocation. This is a naturally occurring process caused by non homologous chromosomes reconfiguring themselves (Khan & Park, 2008). A fusion is then formed when the two or more genes combine. This is most profound in cancer. This occurrence can be detected by cytogenetic of the cells affected. Translocations can either be balanced or unbalanced. When balanced there is exchange that is in consequential to the gene code but for unbalanced it leads to the missing of some genes thus a chromosome imbalance (Nekton, 1989).