Posted: May 22nd, 2023

Bitter Taste Receptors Critical Review

Discovery of Phenylthiocarbamide

Phenylthiocarbamide (herein referred to as PTC) is a compound that was discovered by an organic chemist. The chemist who discovered this compound is Arthur Fox from the United Kingdom.1 The discovery occurred in 1931 when the chemist “accidentally released a plume of fine crystalline powder in his laboratory”1 (par. 1). The compound has a number of unique properties. However, the most conspicuous property of this substance is its bitter taste. Interestingly, Fox determined that not everyone could experience the bitter taste of this compound. Different people detected the taste of this compound differently. For example, there were those who found it to be bitter, while others found it to be mildly bitter. In addition, other people could not detect any bitterness at all.

The compound is still fascinating to researchers in this field, a number of years after its discovery. The researchers are fascinated by the ability of this compound to be detected by the taste buds of certain individuals and remain undetectable by others. Research has shown that the detection of PTC through taste buds is inherited.1 Before DNA technologies gained popularity in the medical field, PTC tasting was used as some sort of paternity test.1To this end, the compound is of profound interest in the field of genetics.

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