Posted: May 22nd, 2023

CD4 T cell also differentiate into another subset along with Th1

CD4 T cell also differentiate into another subset along with Th1, called Th2 (helper T cell 2)which interacts with naive antigen presenting B cells in lymphoid body with the specificity of same antigen as themselves and help activate B cells which differentiate further into antibody producing plasma B cells. Th2 produces cytokines such as IL-4, IL5 and 13, which help in regulating humoral immunity and allergic reactions. Memory T cells are produced in the primary response during the colonial expansion of both short-lived pathogen specific T cell, which work to stop the infection and the long-lived memory T cells that will form future protection against pathogen (Parham 102). Memory T cells increase the speed of secondary response. A clear example of T cell coordinating adaptive immune response is the production of cytokines such as IFN gamma by Th1 cell to regulate adaptive immune response by recruiting inflammatory cells such as macrophages, and dendritic cells to the site of infection to engulf and kill phagocytes.