Posted: May 22nd, 2023

DNase II does not lead to accumulation of ingested DNA in phagocytic cell

These researchers also indicated that a recent study, although not documented, showed that some strains of DNase II-deficient flies had increased expression of antibacterial genes, diptericin, and attacin and this explains partly why the immune system of the flies did not become compromised even after knocking off DNase II. These findings are perplexing because it has been established that accumulation of ingested DNA in phagocytes leads to severely impaired immune system. The conclusion here is that, degradation or mutation of DNase II does not lead to accumulation of ingested DNA in phagocytic cells. Moreover, absence of DNase II does not lead to severely impaired immune system in Drosophila melanogaster.