Posted: May 22nd, 2023
Hematological tests were conducted on the blood samples to measure the hemoglobin concentration, total and differential leukocyte count, erythrocyte count, the blood clotting duration/potential, and the platelet count (Society of Toxicologic Pathologists 1991, p. 290). On the other hand, biochemical analyses were carried out to evaluate the toxicity levels in the kidney and the liver. The samples used for the biochemical analyses were collected after an overnight fasting period (OECD 1998d).
Moreover, histological studies on the kidney, spleen, and other organs were also carried out. On the other hand, toxicokinetic analyses were conducted on the last day of dosing on pre-dose blood samples collected at time points of 10, 30, and 60 minutes and the post-dose blood samples collected at time points of 4, 8, and 24 hours after dosing
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