Posted: May 22nd, 2023

Psychiatric Genetics. Epigenetics and Disease Pathology Essay

The term epigenetics was first coined in the 1940s by Conrad Waddington who described it as the division of biology that investigates the causative exchanges between genes and their upshots, which manifest the phenotype (Sidoli, Cheng & Jensen, 2012; Noble, 2015). Epigenetic modulation involves histone variants, post-translational modifications of amino acids on the amino-terminal tail of histone, and covalent modifications of DNA bases (Moore, 2015). Two forms of epigenetics exist namely molecular and molar, which are also termed as “bottom-up” and “top-down” epigenetics (Crews & Gore, 2014). Molecular epigenetics or epigenotypes revolve around the molecular level analysis while molar or epi phenotypes has its foundation on the rediscovery of Mendel’s research and involves evolution and adaptations as documented in psychobiology and evolutionary biology.

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