Posted: May 22nd, 2023
The implication of this finding is that the mesenchymal stem cells labelled with gadonanotubes are capable of preserving their restorative ability. However, the authors do not quantify the differentiation potential of MSCs labelled with gadonanotubes. Consequently, the authors suggest that additional quantitative examinations are necessary to confirm the abilities of mesenchymal stem cells labelled with GNTs. It is also evident that GNTs alter the cell adhesion properties of mesenchymal stem cells to fibronectin and collagen I, the principal constituents of the extracellular matrix (Tran et al. 2010). MSCs labelled with GNTs exhibit lower adhesion to the extracellular matrix than unlabelled cells. However, the precise mechanisms through which GNTs alter cell adhesion attributes are unknown. The authors recommend that additional investigations be carried out to establish the precise mode of inhibition of cell adhesion. Overall, the authors deduce that gadonanotubes epitomize a novel, high-performance biotechnology for the tagging of stem cells and perhapsÂ in vivoÂ cell tracing using magnetic resonance imaging. These deductions are fully supported by the results of the study. Therefore, it can be concluded that the authors are aware of the gaps in their work that require further investigations.
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