Posted: May 22nd, 2023

The Mode of Action of Morphine

The therapeutic form of morphine preferred by many physicians is Morphine Sulfate (Ebadi 32). It acts as an agonist of the mu receptors. These are specific receptors for morphine that occur in nerve cells. These receptors occur in large numbers in the spinal cord particularly on the Substantia gelatinosa region which harbors many receptors for initial pain signal processing. The confirmation of the morphine receptor allows morphine to bind tightly. The receptor contains a flat point to which the aromatic ring gets attached to, a curved region that holds the two carbon atoms, and lastly, the anionic site that houses the tertiary nitrogen atom. When morphine is bound to its receptor in the CNS, it leads to decreased production of neurotransmitters from the affected neurons. The resultant effect is a decrease in the intensity of pain in the affected regions

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